A Man with Worsening Scaling Plaques and a New Onset Large Draining Ulcerated Tumor

Mycosis Fungoides (MF) is the most common form of cutaneous T-cell lymphoma, a rare condition which typically presents with erythematous patches and plaques, skin nodules and/or tumors. Advanced disease may progress to more aggressive known as large-cell transformation (LCT). MF be easily confused for psoriasis, deep fungal infection, pyoderma gangrenosum. Psoriasis share features associated abnormal functioning T cells, in absence an infectious process, gangrenosum (PG) considered. Definitive diagnosis relies upon histopathology revealing characteristic including cerebriform nuclei, intraepidermal Pautrier microabscesses, epidermotropism haloed lymphocytes, ruling out other etiologies. Here case 62-year-old male atypical LCT who presented worsening eruption large draining ulcerated abdominal plaque. slow indolent multiple treatment options. Brentuximab vedotin (BV) monoclonal antibody targeting CD30 antigen on cancer cells increasingly used patients LCT. The patient was referred hematology/oncology where further workup revealed positive T-cells. He started BV has already shown signs significant regression.